Dr. Ali Sadeghi-Khomami, Precision BioLogic Inc., provided these in-depth technical questions about the Nijmegen Bethesda Assay (NBA), which we use to quantitate specific factor inhibitors such as anti-factor VIII or anti-factor IX. George forwarded his questions to Connie Miller and Amanda Payne, US Centers for Disease Control and Prevention (CDC ) who have been working on NBA accuracy and precision upgrades for several years. Here are Dr. Ali's questions and answers provided by Drs. Miller and Payne; thanks to all for your support.
Posts - Factor Assays
Jun 29, 2017 7:38am
Jun 6, 2017 10:52am
George occasionally receives questions about factor substitution assays. We coagulationists of a "certain age" can recall preparing barium sulfate or aluminum hydroxide "adsorbed" plasma, aged plasma, and serum, then performing mixing studies on prolonged PTT patient plasmas. We mixed the patient plasma 1:1 with pooled normal plasma and the adsorbed and aged plasma and serum,
Sep 20, 2016 6:26pm
The results of our latest Quick Question are in with 87 responses.. How does your laboratory measure factor inhibitors?