2012 Cheat Sheet

Kelly Townsend received a letter stating that BD Vacutainer is recalling a lot of their 2.7 mL sodium citrate tubes due to lithium heparin contamination. Has anyone seen issues with this and how are folks investigating?

Elaine Benoit sent an FDA alert regarding a heparin label change: “This label change will require manufacturers of Heparin Lock Flush Solution, USP and Heparin Sodium Injection, USP to clearly state the strength of the entire container of the medication followed by how much of the medication is in 1 milliliter (mL). These modifications will eliminate the need for health care professionals to calculate the total amount of heparin medication in a product containing more than 1 mL, thereby reducing the risk of miscalculations that may result in medication errors.”

Jasmina Ahluwalia asked if there is any advantage of an LIA assay over ELISA for (VWF :Ag).

George replied the two methods have similar sensitivity, specificity, linearity, and CV% characteristics, however the LIA is usually designed for automated applications, where the analytical time is often less than 10 minutes. The ELISA is usually performed manually, or on an automated fluid manager, and requires approximately 2.5 hours to complete. Your choice depends on how your laboratory is equipped.

Here is a link to the latest EINSTEIN findings comparing rivaroxaban with enoxaparin for treatment of deep venous thrombosis (DVT ) and pulmonary embolism (PE ) reportedDr. Harry Buller at the American Society for Hematology meeting on 12.11.12 in Atlanta, Georgia.

In 2009 Dave McGlasson and George published McGlasson DL, Fritsma GA, Whole blood platelet aggregometry and platelet function testing. Semin Thromb Hemost 2009;35:168–80. This article, the second-most cited in the 2009 Seminars in Thrombosis and Hemostasis, reminded George of our Quick Question about the Ivy bleeding time posted in early November, and subsequently lost when our site crashed in late November. While our goal in posting the Quick Question was to reemphasize the futility of the bleeding time, research led to a lengthy and engrossing article by medical historian Dr. Patricia Spain Ward, 1931–1995, “Who Will Bell the Cat? Andrew C. Ivy and Krebiozen.” The article was published in the Bulletin of the History of Medicine 1984;58:28–52. George prepared a brief summary of the bleeding time test, Ivy’s role in its development, and his subsequent fall from grace when he promoted a false cancer cure, attached to this post.

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