Posts - Lupus Anticoagulant

Mar 11, 2020 9:22am
Maureen (Mo) Tacke, St. Luke's Health System, sent this case. A woman who had experienced one normal fetus loss at longer than 10 weeks' gestation and one unexplained spontaneous miscarriage at shorter than 10 weeks' gestation but no additional thrombotic episodes had the following results:
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Apr 3, 2019 1:09pm
Our Quick Question case study for April, 2019, is adapted from Chapter 35 of the March, 2019 6th edition of Rodak's Hematology, Clinical Principles and Applications:
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Nov 8, 2017 6:36pm
From Dean Willett, Precision BioLogic Inc. As I read the 11-8-17 comments from Dr. Elman a bit of a lightbulb went off in my head.
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Nov 8, 2017 4:11pm
From "Ari." Hi George, I stumbled upon your amazing site when researching this question and was wondering if you could shed some light on this. I have a patient who had a DVT. His PCP noted a slightly prolonged aPTT and sent mixing studies. From what I can tell, the aPTT mostly corrected with mix, but the PTT-LA is definitely long and only slightly corrects (basically it stays prolonged). I understand the PTT-LA results as indicative of a lupus anticoagulant (LAC ) which fits the clinical picture of DVT , but I'm having trouble understanding why the aPTT would correct on mixing. Can you shed some light on this? I've copied the relevant labs with patient identifying factors removed to this link: https://imgur.com/a/e0ubV. (Readers go to the link for the patient data, Geo.)
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